research highlights in WOODRIDGE research highlights WOODRIDGE

research highlights in WOODRIDGE

research highlights WOODRIDGE

research highlights in WOODRIDGE.Is the process of programmed cell death.
From its early conceptual beginnings in the 1950s, it has exploded as an area of research within the life sciences community.
As well as its implication in many diseases, it is an integral part of biological.
It was at this lab that during the 1970s and 1980s, a team led by succeeded in tracing the entire embryonic cell lineage.
Arrived from the us at the lmb in 1974, where he collaborated with sulston.
Both would share the 2002 with brenner, and horvitz would go back to the us in 1978 to establish his own lab at the.
Their observations helped to lead later work toward the genetic pathways of programmed cell death.
They adopted the greek word for the process of leaves falling from trees or petals falling from flowers.
Apo means away, off or apart.
Ptosis means to fall.
They also noted that the characteristic structural changes of apoptosis were present in cells that died in order to maintain an equilibrium between cell proliferation and death in a particular tissue.
Researchers had been hot in the track of , and now more and more of the pieces were falling into place.
Michael hengartner also identified a gene with an opposite effect: ced9.
The product of this gene, which is similar to bcl2 , protects cells from programmed cell death, so its expression conveys a lifeordeath decision on individual cells.
In 1992, it was shown by david vaux and stuart kim at stanford that human bcl2 gene could inhibit programmed cell death in the worm, thus linking programmed cell death and apoptosis revealing them to be the same, evolutionarily conserved process.
In 1994, michael hengartner published a paper showing that ced9 had similar sequence to bcl2.
It identified and reconstituted the mitochondrial pathway to apoptosis and illuminated whole new avenues of research on inflammatory diseases, cancer, and apoptosis in general.